Title: Drug-Induced Sweet Syndrome: A Clinical Case and Review of Management Strategies
Abstract:
Sweet Syndrome (SS), also known as acute febrile neutrophilic dermatosis, is a rare inflammatory skin disorder characterized by the sudden onset of erythematous, painful skin lesions accompanied by systemic symptoms such as fever and elevated white blood cell count. While the condition can occur idiopathically or in association with malignancies, drug-induced SS is increasingly recognized. This article presents a clinical case of drug-induced SS following the initiation of a new inhaled medication and reviews current diagnostic and therapeutic approaches.Introduction:
Sweet Syndrome is a rare condition that presents with acute-onset, tender erythematous plaques or nodules, often accompanied by fever, leukocytosis, and elevated C-reactive protein levels. The pathogenesis involves neutrophilic infiltration of the dermis without evidence of vasculitis. While the exact etiology remains unclear, SS has been classified into three subtypes: classical (idiopathic), malignancy-associated, and drug-induced .
