{"id":2267,"date":"2025-06-04T22:55:32","date_gmt":"2025-06-04T22:55:32","guid":{"rendered":"https:\/\/trendusa1.online\/?p=2267"},"modified":"2025-06-04T22:55:32","modified_gmt":"2025-06-04T22:55:32","slug":"title-drug-induced-sweet-syndrome-a-clinical-case-and-review-of-management-strategies","status":"publish","type":"post","link":"https:\/\/trendusa1.online\/?p=2267","title":{"rendered":"Title: Drug-Induced Sweet Syndrome: A Clinical Case and Review of Management Strategies"},"content":{"rendered":"

Title: Drug-Induced Sweet Syndrome: A Clinical Case and Review of Management Strategies<\/strong><\/p>\n

Abstract:<\/strong>
\nSweet Syndrome (SS), also known as acute febrile neutrophilic dermatosis, is a rare inflammatory skin disorder characterized by the sudden onset of erythematous, painful skin lesions accompanied by systemic symptoms such as fever and elevated white blood cell count.<\/span>\u00a0While the condition can occur idiopathically or in association with malignancies, drug-induced SS is increasingly recognized.<\/span>\u00a0This article presents a clinical case of drug-induced SS following the initiation of a new inhaled medication and reviews current diagnostic and therapeutic approaches.<\/span>Introduction:<\/strong>
\nSweet Syndrome is a rare condition that presents with acute-onset, tender erythematous plaques or nodules, often accompanied by fever, leukocytosis, and elevated C-reactive protein levels.<\/span>\u00a0The pathogenesis involves neutrophilic infiltration of the dermis without evidence of vasculitis.<\/span>\u00a0While the exact etiology remains unclear, SS has been classified into three subtypes: classical (idiopathic), malignancy-associated, and drug-induced<\/span>\u00a0.<\/p>\n

Clinical Case:<\/strong>
\nA 55-year-old female with a history of hypertension and chronic obstructive pulmonary disease (COPD) presented with erythematous, painful lesions on her face and neck, accompanied by low-grade fever.<\/span>\u00a0She had no known drug allergies and was a smoker.<\/span>\u00a0Her medication regimen included enalapril and inhaled formoterol.<\/span>\u00a0Due to worsening pulmonary function, her pulmonologist switched her to a combination inhaler containing indacaterol and glycopyrronium.<\/span>\u00a0Within 48 hours of initiating the new therapy, the patient developed the characteristic skin lesions.<\/span><\/p>\n

Diagnostic Workup:<\/strong>
\nThe patient was referred to dermatology, where a skin biopsy confirmed a dense neutrophilic infiltrate without vasculitis, consistent with SS.<\/span>\u00a0Laboratory tests revealed leukocytosis with neutrophilia and negative autoimmune serologies.<\/span>\u00a0The temporal relationship between the initiation of the new medication and the onset of symptoms suggested a drug-induced etiology<\/span><\/p>\n

Management:<\/strong>
\nThe offending medication was discontinued, and the patient was started on systemic corticosteroids.<\/span>\u00a0Within 48 hours, there was significant improvement in both the skin lesions and systemic symptoms.<\/span>\u00a0This rapid response to corticosteroid therapy is characteristic of SS and supports the diagnosis of drug-induced SS<\/span>\u00a0.<\/p>\n

Discussion:<\/strong>
\nDrug-induced SS is a recognized entity, with several medications implicated, including granulocyte colony-stimulating factors, azathioprine, bortezomib, and antibiotics such as trimethoprim-sulfamethoxazole<\/span>\u00a0.\u00a0The pathophysiology may involve drug-induced cytokine release leading to neutrophil recruitment and activation.<\/span>\u00a0Management primarily involves discontinuation of the offending agent and initiation of systemic corticosteroids.<\/span>\u00a0In refractory cases, alternative therapies such as potassium iodide or colchicine may be considered<\/span>\u00a0.<\/p>\n

Conclusion:<\/strong>
\nSweet Syndrome, particularly the drug-induced form, should be considered in patients presenting with acute-onset erythematous skin lesions and systemic symptoms following the initiation of a new medication.<\/span>\u00a0Early recognition and appropriate management, including discontinuation of the causative drug and initiation of corticosteroid therapy, are essential for favorable outcomes.<\/span>\u00a0Clinicians should maintain a high index of suspicion for SS in such clinical scenarios to ensure timely diagnosis and treatment.<\/span><\/p>\n

Keywords:<\/strong>\u00a0Sweet Syndrome, acute febrile neutrophilic dermatosis, drug-induced, corticosteroids, skin biopsy, neutrophilic infiltrate, medication-induced rash, dermatology, pharmacovigilance, systemic corticosteroids.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Title: Drug-Induced Sweet Syndrome: A Clinical Case and Review of Management Strategies Abstract: Sweet Syndrome (SS), also known as acute febrile neutrophilic dermatosis, is a rare inflammatory skin disorder characterized by the sudden onset of erythematous, painful skin lesions accompanied by systemic symptoms such as fever and elevated white blood cell count.\u00a0While the condition can…<\/p>\n

Read More “Title: Drug-Induced Sweet Syndrome: A Clinical Case and Review of Management Strategies”<\/span> »<\/a><\/p>\n","protected":false},"author":2,"featured_media":2268,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2267","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/trendusa1.online\/index.php?rest_route=\/wp\/v2\/posts\/2267","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/trendusa1.online\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/trendusa1.online\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/trendusa1.online\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/trendusa1.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2267"}],"version-history":[{"count":1,"href":"https:\/\/trendusa1.online\/index.php?rest_route=\/wp\/v2\/posts\/2267\/revisions"}],"predecessor-version":[{"id":2269,"href":"https:\/\/trendusa1.online\/index.php?rest_route=\/wp\/v2\/posts\/2267\/revisions\/2269"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/trendusa1.online\/index.php?rest_route=\/wp\/v2\/media\/2268"}],"wp:attachment":[{"href":"https:\/\/trendusa1.online\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2267"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/trendusa1.online\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2267"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/trendusa1.online\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}